
Krishnashastry brought out many of nuances of great Sanskrit plays of Kālidāsa, Bhavabhuti and Bhasa during his translations to Kannada. He had a good working knowledge of English and German and this helped him to work and translate some of the great works from those languages to Kannada. He was also proficient in Pali, Bengali (self taught), Hindi, and German. Apart from his mother tongue Kannada, he could speak fluently in Sanskrit and English. Some of Krishnashastry notable disciples include Kuvempu, T. Later, similar associations spread throughout Karnataka.
He was the first to start a Karnataka association at the Central College, Bangalore. Krishnashastry was called as Kannada Senani by writer and folklorist H. Krishnashastry married at the age of sixteen to Venkatalakshamma who was only ten at that time. He later served as a professor in Kannada and researcher at the Mysore University until his retirement. He worked as a tutor and a researcher at Oriental Library (later renamed the Oriental Research Institute) at Mysore before enrolling for his Master of Arts degree at the Madras University. His career started as a clerk in the Attara Kacheri (secretariat) in Mysore.

Due to poverty, he was compelled to study Kannada and Sanskrit for his Bachelor of Arts degree (1914) though he wanted to pursue a career as a scientist. Krishnashastry lost his mother to plague when he was ten. His parents were Ramakrishna Shastry, grammarian and principal of Sanskrit school in Mysore and Shankaramma, a home maker. Krishnashastry was born on 12 February 1890, in Ambale, Kingdom of Mysore (in present-day Karnataka, India), into a Smarta Hoysala Karnataka Brahmin family.
